4(3 girls 1 boy),3 week old puppies can be placed immediately if you have the know how and the means to care for a puppy that should still be with its mother. (Very high maintenance but from experience I know that caring for a puppy this early contributes to a very close relationship and commitment to eachother . They are being bottle fed a replacement meant for their age since mom can't do it because she is facing an infection tion that required her to be separated from the puppies. The father is on-site .